October 25, 2018




U.S. Securities and Exchange Commission

Division of Corporate Finance

Washington, DC 20549


Re:Moleculin Biotech, Inc.

Registration Statement on Form S-1

Registration No. 333-227845


Ladies and Gentlemen:


Pursuant to Rule 461 of the Securities Act of 1933, as amended, Moleculin Biotech, Inc., a Delaware corporation (the “Company”), hereby respectfully requests that the effective date for the Registration Statement referred to above be accelerated so that it will be declared effective at 4:30 P.M. (Eastern Time) on October 26, 2018, or as soon thereafter as possible on such date.



  Very truly yours,  
  Moleculin Biotech, Inc.  
  By: /s/ Jonathan Foster  
    Name: Jonathan Foster  
    Title: Chief Financial Officer