Quarterly report pursuant to Section 13 or 15(d)

Commitments and Contingencies - Narrative (Details)

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Commitments and Contingencies - Narrative (Details)
3 Months Ended 6 Months Ended
Aug. 03, 2018
USD ($)
Mar. 22, 2018
USD ($)
ft²
Dec. 04, 2017
USD ($)
Jan. 09, 2017
USD ($)
May 02, 2016
USD ($)
Jun. 30, 2018
USD ($)
Mar. 31, 2018
USD ($)
Jun. 30, 2017
USD ($)
Jun. 30, 2018
USD ($)
employee
Jun. 30, 2017
USD ($)
Commitments and Contingencies [Line Items]                    
Payments to HPI over three-year period         $ 750,000          
Buy-out option payment to HPI         $ 1,000,000.0 $ 1,000,000.0     $ 1,000,000.0  
Licensing agreement, term         3 years          
Sponsored laboratory study agreement expense           4,231,000   $ 515,000 $ 5,469,000 $ 1,199,000
Employee agreements, special termination benefits, number of employees | employee                 8  
Employee agreements, termination benefits provided to key employees, aggregate amount                 $ 1,100,000  
MD Anderson                    
Commitments and Contingencies [Line Items]                    
License costs                 200,000 100,000
MD Anderson                    
Commitments and Contingencies [Line Items]                    
License costs           100,000   100,000    
Payments for research and development agreement     $ 350,000 $ 300,000     $ 240,000      
Sponsored laboratory study agreement expense           90,000.00   40,000.00 180,000 80,000.00
Houston Pharmaceuticals, Inc                    
Commitments and Contingencies [Line Items]                    
License costs           1,100,000   $ 100,000 1,200,000 $ 100,000
Lease Agreement For Corporate Office Space | IPX Memorial Drive Investors, LLC                    
Commitments and Contingencies [Line Items]                    
Leased office space (in square feet) | ft²   2,333                
Term of operating lease (in months)   66 months                
Operating lease, renewal term (in years)   5 years                
Operating lease, monthly rent expense   $ 4,300                
Operating lease, rent expense, annual increase in rent, percent   3.00%                
Maximum                    
Commitments and Contingencies [Line Items]                    
Payments for royalties                 600,000  
Maximum | MD Anderson                    
Commitments and Contingencies [Line Items]                    
License agreement, annual license fee                 100,000  
Maximum | MD Anderson | Commencement of Phase II and Phase III Clinical Trials                    
Commitments and Contingencies [Line Items]                    
Milestone payments liabilities           500,000     500,000  
Maximum | MD Anderson | Submission Of NDA And Receipt Of First Marketing Approval For Sale Of A Licensed Product                    
Commitments and Contingencies [Line Items]                    
Milestone payments liabilities           $ 600,000     $ 600,000  
Subsequent Event | MD Anderson                    
Commitments and Contingencies [Line Items]                    
Payments for research and development agreement, next twelve months $ 110,000