Quarterly report pursuant to Section 13 or 15(d)

Commitments and Contingencies - Narrative (Details)

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Commitments and Contingencies - Narrative (Details) - USD ($)
1 Months Ended 3 Months Ended 9 Months Ended 12 Months Ended
Aug. 31, 2019
Apr. 30, 2019
Feb. 19, 2019
Mar. 22, 2018
May 02, 2016
Oct. 31, 2019
Jun. 30, 2019
Sep. 30, 2018
Sep. 30, 2019
Sep. 30, 2018
Jun. 30, 2018
Sep. 30, 2019
Sep. 30, 2018
Dec. 31, 2017
Dec. 31, 2015
Aug. 08, 2019
Jul. 30, 2019
Dec. 31, 2018
Commitments and Contingencies                                    
Sublease income                 $ 3,400                  
Lease cost                 20,000.00     $ 30,000.00            
Short-term lease cost                 10,000.00     40,000.00            
Variable lease cost                 $ 10,000.00     $ 20,000.00            
Minimum lease payments, year one                                   $ 48,000
Minimum lease payments, year two                                   53,000
Minimum lease payments, year three                                   54,000
Minimum lease payments, year four                                   55,000
Minimum lease payments, year five                                   56,000
Minimum lease payments, thereafter                                   $ 5,000
Weighted average remaining term                 4 years 5 months 1 day     4 years 5 months 1 day            
Operating lease, weighted average discount rate (percent)                 9.60%     9.60%            
Payments to HPI over three-year period         $ 750,000                          
Payments for research and development agreement         $ 1,000,000.0           $ 1,000,000.0              
HPI out-licensing agreement term         3 years                          
Research and development                 $ 2,785,000 $ 1,332,000   $ 7,816,000 $ 6,801,000          
Common stock, shares, issued (in shares)                 45,727,700     45,727,700           28,528,663
Employee agreements, termination benefits provided to key employees, aggregate amount                       $ 900,000            
WPD Pharmaceuticals | First Two Years                                    
Commitments and Contingencies                                    
Research and development commitment     $ 2,000,000.0                              
WPD Pharmaceuticals | After Two Years                                    
Commitments and Contingencies                                    
Research and development commitment     1,000,000.0                              
MD Anderson | License                                    
Commitments and Contingencies                                    
Cost of services                 $ 100,000 100,000   200,000 200,000          
Olympia Drive W Bellfort, LLC                                    
Commitments and Contingencies                                    
Term of operating lease (in months) 35 months                                  
Operating lease, rent expense, annual increase in rent (as a percent) 3.00%                                  
Sublease income                       $ 3,400            
Weighted average remaining term                 2 years 10 months 2 days     2 years 10 months 2 days            
Houston Pharmaceuticals, Inc.                                    
Commitments and Contingencies                                    
Percentage of rents payable by co-lessee 50.00%                                  
Percentage of Sub-lease income allocable to co-lessee 50.00%                                  
Option repurchase payment   $ 1,000,000.0                                
Houston Pharmaceuticals, Inc. | License                                    
Commitments and Contingencies                                    
Cost of services                 $ 0.0 100,000   $ 100,000 1,200,000          
MD Anderson                                    
Commitments and Contingencies                                    
Payments for research and development agreement             $ 400,000 $ 400,000           $ 300,000        
Research and development                 200,000 $ 100,000   400,000 $ 300,000          
MD Anderson | Subsequent Event                                    
Commitments and Contingencies                                    
Payments for research and development agreement           $ 400,000                        
Dermin                                    
Commitments and Contingencies                                    
Future payment to remove Germany                             $ 500,000      
Equity distribution commitment                                 $ 500,000  
Common stock, shares, issued (in shares)                               429,978    
WPD Pharmaceuticals                                    
Commitments and Contingencies                                    
Future payment to remove Germany     $ 500,000                              
Lease Agreement For Corporate Office Space | IPX Memorial Drive Investors, LLC                                    
Commitments and Contingencies                                    
Term of operating lease (in months)       66 months                            
Operating lease, renewal term (in years)       5 years                            
Operating lease, rent expense, annual increase in rent (as a percent)       3.00%                            
Maximum                                    
Commitments and Contingencies                                    
Payments for royalties                       600,000            
Maximum | MD Anderson                                    
Commitments and Contingencies                                    
License agreement, annual license fee                       100,000            
Milestone payments liabilities                 500,000     500,000            
Maximum | MD Anderson | Submission Of NDA And Receipt Of First Marketing Approval For Sale Of A Licensed Product                                    
Commitments and Contingencies                                    
Milestone payments liabilities                 $ 600,000     $ 600,000